Erratum for Boudry et al., Function of the CRISPR-Cas System of the Human Pathogen Clostridium difficile
نویسندگان
چکیده
Pierre Boudry,a,b Ekaterina Semenova,c Marc Monot,a Kirill A. Datsenko,d Anna Lopatina,e Ognjen Sekulovic,f Maicol Ospina-Bedoya,f Louis-Charles Fortier,f Konstantin Severinov,c,e Bruno Dupuy,a Olga Soutourinaa,b Laboratoire Pathogenèse des Bactéries Anaérobies, Institut Pasteur, Paris, Francea; Université Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, Paris, Franceb; Waksman Institute of Microbiology, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USAc; Purdue University, West Lafayette, Indiana, USAd; Institutes of Molecular Genetics and Gene Biology, Russian Academy of Sciences, Moscow, Russiae; Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Canadaf
منابع مشابه
Function of the CRISPR-Cas System of the Human Pathogen Clostridium difficile
UNLABELLED Clostridium difficile is the cause of most frequently occurring nosocomial diarrhea worldwide. As an enteropathogen, C. difficile must be exposed to multiple exogenous genetic elements in bacteriophage-rich gut communities. CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) systems allow bacteria to adapt to foreign genetic invaders. Our recent...
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Infectious diseases remain a global threat with many people annually contracting the epidemic diseases. Improved understanding of the pathogenesis of bacteria, viruses, fungi, and parasites, along with rapid diagnosis and treatment of human infections are essential to improving infectious diseases outcomes worldwide. In many genomic loci in bacteria and archea, termed Clustered Regularly Inters...
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UNLABELLED Clostridium difficile is an important human-pathogenic bacterium causing antibiotic-associated nosocomial infections worldwide. Mobile genetic elements and bacteriophages have helped shape C. difficile genome evolution. In many bacteria, phage infection may be controlled by a form of bacterial immunity called the clustered regularly interspaced short palindromic repeats/CRISPR-associ...
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Virulent strains of Clostridium difficile have become a global health problem associated with morbidity and mortality. Traditional typing methods do not provide ideal resolution to track outbreak strains, ascertain genetic diversity between isolates, or monitor the phylogeny of this species on a global basis. Here, we investigate the occurrence and diversity of clustered regularly interspaced s...
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Clostridium difficile is an emergent pathogen, and the most common cause of nosocomial diarrhea. In an effort to understand the role of small noncoding RNAs (sRNAs) in C. difficile physiology and pathogenesis, we used an in silico approach to identify 511 sRNA candidates in both intergenic and coding regions. In parallel, RNA-seq and differential 5'-end RNA-seq were used for global identificati...
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